Bosses are found on Assassination missions. Each boss has a set of lines to "taunt" the Tenno sent to kill them. They drop mods and resources upon death. Depending on which Boss the player is fighting, Blueprints of Warframes parts and special Weapons parts will often be rewarded upon mission completion.
- All Assassination missions that award Warframe parts have a 38.7% chance to reward Helmets, 38.7% Chance to reward Chassis, and 22.6% chance to reward Systems.
On the other hand Assassins hunt players in random locations. Their appearance are triggered by various actions done by the player, such as killing a Boss or assisting an opposing Factions in Invasion missions.
Captain Vor Is one of the few figures in the game that understands ancient Orokin technology, going as far as utilizing it and merging it with Grineer technology to create offensive weapons such as his trademark Seer pistol and also his armor, which is powered by a Void Key and grants him a powerful ranged beam attack. Captain Vor can be encountered in three locations currently, making him the most recurring boss beside assassins. First appearing on Mercury and thus being the first boss that players must fight, he then appears again, somehow fully alive, on Phobos as a dual boss battle alongside Lieutenant Lech Kril, then appearing later yet again as a Corrupted version of himself within the Void.
- 主条目: Councilor Vay Hek
Councilor Vay Hek is the hidden boss located on a secret base on Earth. He is the most political Grineer figure players meet, marked by the Lotus for extermination for upsetting the balance in the system by killing several political opponents. Paranoid for being targeted, Vay Hek now hides in a secret location in which players must extract Beacons found from Prosecutors on Ceres Grineer Shipyard in order to find him. Vay Hek is also heavily modified with Grineer alterations, with little flesh left noticeable while he rides in his giant Terra Frame machine.
- 主条目: Kela De Thaym
Kela De Thaym is the boss of Sedna. According to the Lotus, all female Grineer undergo combat training. However, in Kela's case, she was the most battle hungry and extended her own term another decade before returning to the Grineer council. She has influence within the council, which is the main reason why the Lotus has targeted her for assassination as her death would cause a power vacuum in the system. The only female Grineer boss players encounter, she was specifically built for combat personally by the Sisters, with most of her body replaced with augmentations.
- 主条目: Lieutenant Lech Kril
Lieutenant Lech Kril is the final boss of Ceres, and makes an appearance on Phobos alongside Captain Vor as a dual boss battle on the planet. A revered war hero to the Grineer, Lotus has targeted Kril so that his death could create possible instability within the Grineer and intimidate them, although she also fears he may become a martyr with Grineer riled up to avenge his death as a result. His rank as a "war hero" is rather strange considering his apparent low rank in the Grineer military, although his near impenetrable body suit and massive temper may prove that he is indeed as ruthless as Grineer say he is.
- 主条目: Tyl Regor
Tyl Regor is the final boss of the Uranus system and the head researcher focusing on Grineer gene repair in an attempt to reverse the negative effects from excessive cloning. He was targeted by the Lotus in order to slow down this progress, ensuring that the Grineer do not become more powerful. He apparently has an interest in fashion somewhat, as some of his remarks in the mission hint at, such as mocking the player's warframe by comparing it to a halloween costume.
- 主条目: Alad V
Alad V 是對Grineer外交部的首長，並且直接對議事會負責。雖然處於這樣的位置，Alad V對Grineer表示出特別的輕蔑(其被他稱之為"畜生們")，而對於Tenno們則較為尊重。因為他出現在許多活動 中的關係，他是被描述的最多的Corpus頭目。他最終著迷於研究Infested，因為有可能可以創造強力的生化結合武器：如被應用在他自身的護甲上的科技細胞病毒，並犧牲了他的 Zanuka 計畫
- 主条目: Ambulas
- 主条目: Hyena Pack
The Hyena Pack are the final bosses of the Neptune system, made up by 4 unique and deadly variants of the Hyena proxy. They work in packs of up to four with each of them possessing a unique set of abilities. Each Hyena possesses a plasma repeater and are far more agile than any other enemy in the game, including Zanuka and Zanuka Hunter. Alongside their agility, they can also jump on to and cling to walls, though they cannot wallrun. Lotus has marked them for assassination for obvious reasons, as they are a very dangerous proxy group and destroying the models may slow down further production.
- 主条目: Jackal
Jackal is the final boss of the Venus system, and represents the first Corpus boss that players encounter. Although a more bulky and old model compared to more recent Corpus robotics, the Jackal possesses invulnerable shields, a giant shockwave ability to knock players down, and one of the most powerful corpus weapons, the Plasma Grenade Cluster. Dissected models of the Jackal can be found in some Grineer tilesets, either showing that the Grineer have interest in utilizing Corpus technology, or that they are simply purchased merchandise.
- 主条目: Lynx
The Lynx is a miniboss that is encountered in certain Orokin Sabotage tiers that feature Corpus enemies, acting as the main miniboss from which the mission's Void Key drops from. It resembles a smaller Jackal with blue armor, and has the ability to deploy Osprey drones and Turrets to assist it in combat.
- 主条目: Raptor
The Raptor is a Corpus Boss found in the Europa system, and the only flying Corpus boss in the game. It has very high stats and heavy hitting weapons, including launching high damage missiles that seek players, deploying mines and firing explosive laser bolts, making fighting in the open a difficult task. It was marked for assassination for being a high threat risk, as more models of this proxy could result in dangerous repercussions.
- 主条目: Phorid
Phorid is an infested boss, found when an infested invasion manages to "Infest" the boss node. After defeating it and finishing the mission, you receive Nyx Helmet, Chassis, or Systems Blueprint. Upon death, Phorid has a chance of dropping rare Resources of the planet he has appeared.
Assassins are boss-like NPC's that hunt players in random locations after doing certain things against their Factions, earning their respective Death Marks in the process. In the Stalker's case, he will target players who have defeated one of the regular enemy bosses in the game as "revenge". The Zanuka Hunter and The Grustrag Three will target the player when they aid the opposing faction in an Invasion mission. They usually drop rare resources and exclusive weapons when defeated.
- 主条目: The Grustrag Three
The Grustrag Three (commonly abbreviated as the G3) is a group of Assassins founded by Councilor Vay Hek, which comes after a Tenno who has completed at least one Invasion mission against the Grineer.
- 主条目: Zanuka Hunter
Zanuka 猎犬, also known as Harvester is a gray-colored Zanuka proxy controlled by Alad V. During missions, it will attack one targeted Tenno until either the Tenno or the Zanuka 猎犬 dies. It appears rarely, in a manner similar to the Stalker.
- 主条目: Stalker
- All bosses and assassins have a rare chance to drop an Orokin Cell upon death. This chance is fully separate from the planet's resource drop rate.
|Grineer||Balor Fomorian • Vor上尉 • Vay Hek議員 • Sargas Ruk將軍 • Kela De Thaym • Lech Kril中尉 • Tyl Regor • Ven'kra Tel & Sprag|
|Corpus||Alad V • Ambulas • 豺狼 • Nef Anyo中士 • 鬣狗(包) • 山貓 • 猛禽|
|Infested||Infested Mesa • 異融者Alad V • Phorid • Lephantis• Jordas Golem|
|The Grustrag Three • Zanuka Hunter • Stalker|